Bunnie Xo, the host of the popular “Dumb Blonde” podcast, recently shared her experience using a weight-loss drug called tirzepatide (also known by the brand names Mounjaro or Zepbound).
Bunnie, who’s also on tour with her husband, country artist Jelly Roll, took a shot of the medication but faced some intense side effects that left her wondering if she’d ever use it again.
Tirzepatide, originally approved to treat diabetes, has also been approved for weight loss after studies showed it could help people lose up to 22.5% of their body weight.
It’s an injectable medication, usually taken in the thigh, stomach, or arm, and works by reducing appetite and helping the body process sugars and fats better.
For people struggling with obesity or related health conditions, it can be a game-changer. But as Bunnie’s experience shows, not everyone’s body reacts the same way to it.
Bunnie, 44, wasn’t taking tirzepatide to lose weight. Instead, she wanted help with hormone balance and inflammation issues, particularly because she suspects she has a hormonal condition known as Polycystic Ovary Syndrome (PCOS).
PCOS is a common condition that can lead to hormone imbalance, weight gain, and difficulty processing insulin. It can also cause small fluid-filled sacs to develop around the ovaries, making some people prone to weight gain and other symptoms.
“I would love to have, you know, about 10 lbs. off of me, but I’m taking it for the inflammation and to regulate my hormones,” she explained.
But her first few days on the drug were anything but smooth. In an episode of her podcast, she told listeners that she felt fine for most of the first day but then was suddenly hit with severe nausea late at night. “I felt like I was gonna f—— projectile vomit,” she said. And by the fifth day, things had gone from bad to worse. “By this time, I had diarrhea for days. I was dehydrated so bad,” she explained. Thankfully, because she was on tour with Jelly Roll, she had access to a nurse who could help. The nurse gave her two IV bags and some magnesium, which helped her feel a lot better.
“After that, I was fine,” Bunnie said. But the experience left her shaken. “I just feel like I have a chemical in my body, and I don’t love it.”
Despite the rough side effects, Bunnie did mention some positive changes. She’s lost 4 lbs. in just two weeks, going from 160 lbs. to 157.2 lbs., and she’s even been sleeping better than she usually does. “On Trizeppy, I have been getting, like, eight hours of sleep, and it has been so great,” she shared. But overall, the experience has left her questioning if this is the right choice for her body.
Bunnie joked about how strange it felt to be making headlines for her health issues. “I’m never gonna be a sex symbol because I only make headlines for how I wear diapers and s— myself,” she laughed, making light of the situation. But she also took the time to caution her followers, especially those considering tirzepatide for themselves. “If you’re super sensitive to things like I am and I don’t even wanna take aspirin … I’m literally, like, just raw-dogging life over here,” she said. She described her reaction as a reminder that even medications that work well for some people may not suit everyone.
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